Akinetic Mutism Caused by HIV-associated Progressive Multifocal Leukoencephalopathy was Successfully Treated with Mefloquine: A Serial Multimodal MRI Study
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- Naito Kasane
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan Department of Neurology, Hiroshima City Hospital, Japan
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- Ueno Hiroki
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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- Sekine Mayu
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan Department of Neurology, Tokyo Saiseikai Central Hospital, Japan
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- Kanemitsu Munekazu
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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- Ohshita Tomohiko
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan Department of Neurology, Suiseikai Kajikawa Hospital, Japan
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- Nakamura Takeshi
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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- Yamawaki Takemori
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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- Matsumoto Masayasu
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
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Abstract
We report a case of a patient with highly active anti-retroviral therapy-resistant human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML). The patient showed an improvement in imaging findings and clinical symptoms after mefloquine was introduced as an additional treatment. Serial assessment of white matter lesions was conducted by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted imaging (DWI). As the clinical symptoms improved, the N-acetylaspartate/creatine ratio increased, the choline/creatine ratio decreased, and the elevated ADC value decreased. These concomitant changes suggested that 1H-MRS and DWI were useful for the assessment of the therapeutic effect on PML.<br>
Journal
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- Internal Medicine
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Internal Medicine 51 (2), 205-209, 2012
The Japanese Society of Internal Medicine
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Details
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- CRID
- 1390001204870305920
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- NII Article ID
- 130002062062
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- COI
- 1:CAS:528:DC%2BC38XhsV2jtLvO
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- ISSN
- 13497235
- 09182918
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- PubMed
- 22246492
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed