Neuropharmacokinetic Heterogeneity of Mefloquine in the Treatment of Progressive Multifocal Leukoencephalopathy

DOI DOI Web Site Web Site PubMed ほか1件をすべて表示 一部だけ表示 被引用文献6件 参考文献24件 オープンアクセス
  • Naito Kasane
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan Department of Neurology, Hiroshima City Hospital, Japan
  • Ueno Hiroki
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
  • Sekine Mayu
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan Department of Neurology, Tokyo Saiseikai Central Hospital, Japan
  • Kanemitsu Munekazu
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
  • Ohshita Tomohiko
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan Department of Neurology, Suiseikai Kajikawa Hospital, Japan
  • Nakamura Takeshi
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
  • Yamawaki Takemori
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan
  • Matsumoto Masayasu
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Japan

書誌事項

タイトル別名
  • Akinetic Mutism Caused by HIV-associated Progressive Multifocal Leukoencephalopathy was Successfully Treated with Mefloquine: A Serial Multimodal MRI Study

この論文をさがす

説明

We report a case of a patient with highly active anti-retroviral therapy-resistant human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML). The patient showed an improvement in imaging findings and clinical symptoms after mefloquine was introduced as an additional treatment. Serial assessment of white matter lesions was conducted by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted imaging (DWI). As the clinical symptoms improved, the N-acetylaspartate/creatine ratio increased, the choline/creatine ratio decreased, and the elevated ADC value decreased. These concomitant changes suggested that 1H-MRS and DWI were useful for the assessment of the therapeutic effect on PML.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 51 (2), 205-209, 2012

    一般社団法人 日本内科学会

被引用文献 (6)*注記

もっと見る

参考文献 (24)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ