Ghrelin, a Novel Orexigenic Peptide from theStomach, and the Relationship between Body, Brain and Mind

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  • Naruo Tetsuro
    Department of Psychosomatic Medicine, Kagoshima University Hospital

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  • 新いい消化管ホルモン : グレリンからみた心身相関(第42回日本心身医学会総会)
  • 新しい消化管ホルモン-グレリンからみた心身相関
  • アタラシイ ショウカカン ホルモン グレリン カラ ミタ シンシン ソウカン

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Abstract

Ghrelin which has been searched as a specific endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and which was isolated from the stomach of a rat at last has a naturally powerful stimulus action growth hormone secretion. Furthermore, it was shown clearly that ghrelin had various physiological functions such as powerful appetite rise action, and other actions in the circulatory organ system, in the central nervous and the bone metabolism systems. Especially, in starvation, much of ghrelin, which is secreted by peripheral internal organs mainly in the stomach, reaches to vagal nuclei of the medulla oblongata through the whole body circulation and connects both directions of the afferent way going to hypothalamus and the efferent way going to the stomach. Furthermore, ghrelin-producing cells also exist in the arcuate nucleus which is also the center of an appetite regulation system. They act competitively on the leptin which has an appetite reduction action by the NPY/AgRP neuron. In clinical research, in was clarified that the concentration in the blood was reverse-correlated with weight, and decreasing from immediately after meal ingestion. In eating disorders, it is also made clear that habitual vomiting raises the concentration in blood. Thus, further unknown physiological functions of ghrelin are assumed. I think that these actions play an important role in the mind-and-body correlation by connecting the center to the tip, maintaining various physiological functions.

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