血清SCC抗原高値の原因が高分子量SCC抗原であった3症例

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  • Three Cases of Falsely Elevated Levels of Serum SCC Antigen Due to Formation of High Molecular Weight SCC Antigen

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We determined levels of squamous cell carcinoma (SCC) antigen in sera obtained from three patients with sustained high levels but without evidence of carcinoma. High-performance liquid chromatography (HPLC) revealed two to three SCC antigen peaks, one of which eluted at the authentic molecular weight, and the others at a larger one. The sera were not adsorbed by antibodies to IgG, IgA or IgM, and were not inactivated by heating at 56° for 30 min. We demonstrated that the rise in serum SCC antigen in patients without carcinoma could be attributed to the larger molecular weight forms.

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