肝胆道疾患におけるアポ蛋白A-IおよびA-II測定の臨床的意義
書誌事項
- タイトル別名
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- Clinical Evaluation of Apoprotein A-I and A-II in Patients with Hepatobiliary Diseases
抄録
The serum apoproteins A-I and A-II concentrations were determined in124 patients with hepatobiliary diseases and30normal subjects.The determination of these apoproteins by single radial immunodiffusion was highly corre-ated with that by electroimmunoassay.<BR>The mass of apoproteins A-I and A-II, the major proteins of high-density lipoprotein (HDL), decreased in many liver parenChymal diseases and obstructive jaundice. But, the ratio of apoprotein A-I to A-II increased only in the decompensated stage of liver cirrhosis and obstructive jaundice-The amounts of apoproteins A-I and A-II in hepatobi-iary diseases correlated with HDL3-cholesterol (d=1.063-1.125).The clinical course of apoproteins A-I and A-II in one patient with subacute hepatitis showed the discrepancy with HDL-cholesterol, and the histological findings of biopsy specimen were identifiable with the amounts of the former than that of the latter.The amounts of apoproteins A-I and A-II correlated strognly with conventional liver functional tests (e.9., albumin, choline-esterase, total protein, lecithin-cholesterol acyltransferase).<BR>These results indicate that apoproteins A-I and A-II are metabo-ized somewhat independently of each other and the lipid components in HDL.We must, therefore, measUre apoproteins as well as lipid moieties when -ooking at patlents with hepatobiliary diseases.
収録刊行物
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- Japanese Journal of Clinical Chemistry
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Japanese Journal of Clinical Chemistry 12 (4), 319-326, 1983
一般社団法人 日本臨床化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204912114304
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- NII論文ID
- 130003357901
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- ISSN
- 21874077
- 03705633
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可