A Resected Case of Hepatosplenic Malignant Lymphoma with Hepatitis B Virus Infection

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  • Ｂ型肝炎ウィルス感染を伴った肝脾悪性リンパ腫の１切除例

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We report to our knowledge the first case of resected hepatosplenic malignant lymphoma. A 55-year-old Jehovah's Witness woman underwent abdominal CT showing solid masses in the liver and spleen. Superficial lymph nodes were not palpated. Laboratory data showed LDH of 711 IU/l, positive HBsAg, and IL-2R of 748 U/ml. A liver biopsy showed diffuse multiplication of large B cell type lymphocytes. A diagnosis of malignant lymphoma localized in the liver and spleen was made by bone marrow tap, head MRI, and FDG-PET. Because of impending tumor rupture, we conducted lateral segmentectomy of the liver followed by splenectomy. THP-COP therapy was conducted postoperatively in 3 courses. She has had no recurrence in 3 years.

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