血液型（抗Ｄｉｂ）不適合妊娠に対する新しい母体治療の経験　免疫吸着剤（ＩＭ‐Ｐ３５０）による血しょう浄化法の応用

DOI

書誌事項

タイトル別名
  • A new method for the treatment of blood group-incompatible pregnancy.

抄録

Using an immunoadsorbent column (IM-P), we have found an effective treatment of blood group incompatible pregnancy (anti Diego b) with minimum side effects. The patient had a history of blood transfusion given at 12 years of age, and her first child had required exchange transfusion. She had a high titer of IgG anti-Dib before this pregnancy. Because the ΔOD 450 values of the amniotic fluid were elevated to zone 2 A of Liley's graph at 32 weeks of gestation, we performed plasma cleaning with IM-P. After the first treatment, the ΔOD 450 value fell to zone 3 of Liley's graph, and the anti-Dib titer in the maternal blood was kept at low levels by three more plasma cleanings until delivery. A viable mature but anemic newborn was delivered at 38 weeks of gestation and required exchange transfusion.<BR>The immunoadsorbent column (IM-P) is a muliporous polyvinyl alcohol gel, on which surface phenylalanine is immobilized as a ligand. This column has been used for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients. As plasma protein did not decrease after plasma cleaning with this column, neither fresh frozen plasma nor plasma protein fraction was required for this procedure. They are required for plasmapheresis and sometimes cause hepatitis. Plasma IgG and IgA values fell sligtly with this treatment, but no other abnormal values were noted.This immunoadsorbent column may be applicable for the management of other blood type incompatible pregnancies.

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詳細情報 詳細情報について

  • CRID
    1390001204946777600
  • NII論文ID
    130004188049
  • DOI
    10.11437/sanpunosinpo1949.42.499
  • ISSN
    13476742
    03708446
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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