脳卒中の感情失禁に対するβ‐遮断薬の効果について

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  • Effects of Beta-Blocker on Emotional Incontinence in Stroke Patients.
  • ノウソッチュウ ノ カンジョウ シッキン ニ タイスル ベータ シャダンヤク

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Several kinds of β-blocker were given orally to 23 patients with emotional incontinence after stroke. By the treatment for more than 2 weeks, the symptom improved markedly in 26.1%, moderately in 26.1% and slightly in 13.0%. Cessation of medication in 6 patients showing the improvement of emotional incontinence resulted in the evident aggravation of the symptoms in 5 patients within a week. There was no difference in the efficacy of β-blockers due to sex, age and the site of brain damage.<br>Propranolol and atenolol which were different in hydrophobicity, i. e. blood brain barrier-permeability and β1, 2 receptor selectivity were similarly effective. These results would suggest that the effects of β-blocker on emotional incontinence is attributable to the suppression of central β1-adrenergic mechanisms related to the generation or expression of emotion, and that blood brain barrier is damaged in stroke patients. Although more detailed studies on doses and indications are required, β-blocker is expected as an effective tool for emotional incontinence after stroke.

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