EXAMINATION OF EFFECTIVENESS OF OLOPATADINE HYDROCHLORIDE IN ATOPIC DERMATITIS

Shimizu Tadamichi, Mashiko Maki, Shimizu Hiroshi

doi:10.15036/arerugi.54.68

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アトピー性皮膚炎に対する塩酸オロパタジンの有効性の検討
アトピーセイヒフエンニタイスルエンサンオロパタジンノユウコウセイノケントウ

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Subjective/objective symptoms (itching, papula, erythema, lichenification, desquamation, scratching, erosion) and the levels of IgE, LDH, interleukin (IL)-6, thymus and activation-regulated chemokine (TARC) were compared before and after administering olopatadine hydrochloride (ALLELOCK(R) tablets) to 17 atopic dermatitis (AD) patients. Subject/objective symptoms improved significantly after administering the agent, and the total dosage of the combined topical steroids was also significantly decreased after administration (p<0.05), although IgE, IL-6 and LDH levels did not change. TARC was significantly decreased (p<0.05). The correlation between the levels of IgE, IL-6, LDH and TARC before and after the administration was examined. There was a positive correlation between IgE and TARC (r=0.62, p<0.01) and between IL-6 and TARC (r=0.78, p<0.01). Olopatadine hydrochloride is therefore useful in improving the symptoms in AD, and TARC may be used as an indicator of the symptom improvement.

Journal

Japanese Journal of Allergology

Japanese Journal of Allergology 54 (2), 68-75, 2005

Japanese Society of Allergology

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