血しょうEndothelin‐1値における加齢の影響について

書誌事項

タイトル別名
  • Changes in the Level of Endothelin-1 with Aging.

抄録

Endothelin-1 (ET-1) is a potent and long-lasting vasoconstrictor peptide. In order to clarify the changes in the level of ET-1 with aging, we measured the ET-1 level in plasma by radioimmunoassay and used 74 healthy subjects including 61 males and 13 females, aged from 30 to 69, who were admitted in the health check center of Ashikaga Red Cross Hospital. None of them had risk factors related to hypertension, obesity, diabetes mellitus or cardiovascular disease. In the male group, the relationship between the level of ET-1 (Y) and age (X) was obtained as follows: Y=0.08857X+0.06363. The correlation between them was significant (γ=0.65894, p<0.05). In the female group also, the increased level of ET-1 (Y) with age (X) showed an excellent linear relationship (Y=0.163091X-4.23, γ=0.762, p<0.002). These studies demonstrated that the level of ET-1 increased in relation to aging and the increased ET-1 production with aging may be consistent with deterioration of endothelial function.

収録刊行物

被引用文献 (1)*注記

もっと見る

詳細情報 詳細情報について

  • CRID
    1390001205021867392
  • NII論文ID
    130003444322
  • DOI
    10.3143/geriatrics.32.664
  • COI
    1:STN:280:DyaK287ktl2kug%3D%3D
  • ISSN
    03009173
  • PubMed
    8551691
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ