書誌事項
- タイトル別名
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- Expression of Decay-accelerating Factor on CD8-positive Lymphocytes as an Index of Aging and of Host Defense Function.
- ロウカ ト セイタイ ボウギョノウ ノ シヒョウ トシテノ リンパキュウジョウ
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抄録
Decay-accelerating factor (DAF) is a membrane glycoprotein that prevents complement activation on blood cells. Among CD8+ T cells, DAF-negative cells can be distinguished from DAF-positive cells. We computed the proportion of DAF-negative CD8+ T cells in the peripheral blood of 59 normal healthy subjects, 27 to 93 years old, and analyzed the differences between subjects of different ages. The proportion of CD8+ T cells that were DAF-negative correlated significantly and positively with age. We also studied these lymphocytes in patients with cerebrovascular dementia, Alzheimer's dementia, cancer, rheumatoid arthritis and systemic lupus erythematosus. The proportion of CD8+ T cells that were DAF-negative did not correlate significantly with age in patients with cerebrovascular dementia, Alzheimer's dementia or cancer, but it correlated significantly and positively with age in patients with rheumatoid arthritis and in those with systemic lupus erythematosus. Therefore, healthy subjects and patients with various diseases can be classified according to age and to the proportion of CD8+ T cells that are DAF-negative. This proportion can then be used as an index of aging and of host defense function.
収録刊行物
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- 日本老年医学会雑誌
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日本老年医学会雑誌 33 (8), 580-585, 1996
一般社団法人 日本老年医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205023288704
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- NII論文ID
- 130003652246
- 10013851773
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- NII書誌ID
- AN00199010
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- NDL書誌ID
- 4048068
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- ISSN
- 03009173
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- PubMed
- 8921695
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可