Acquired Amylase Production Induced by Radiotherapy in a Myeloma Patient

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  • YAMAKAWA Tamami
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • NAGOSHI Haruhisa
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • TAKAHASHI Atushi
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • FUKUMURA Reiko
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • TAKAHASHI Shigeaki
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • NOMURA Machiko
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • ISOBE Hozumi
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • IDE Kiyoshi
    The Third Department of Internal Medicine, St. Marianna University School of Medicine
  • AYABE Teruhisa
    Department of Internal Medicine, Chuusun Red Cross Hospital
  • SHIMIZU Susumu
    Department of Internal Medicine, Chuusun Red Cross Hospital

Bibliographic Information

Other Title
  • 放射線治療によるアミラーゼ産生性の誘導が示唆された多発性骨髄腫

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Description

A 55-year-old patient with multiple myeloma (IgG-λ) diagnosed in November 1988 was admitted because of bone pain throughout the body. After plasmapheresis and several courses of chemotherapy, a massive tumor of the left thoracic wall involving the rib appeared. Radiotherapy was performed to ameliorate the severe chest pain, after which myelomatous pleural effusion appeared on the left side. The serum, urine and pleural effusion revealed increased activity of amylase of the salivary type. Amylase activity was also detected in the supernatant of myeloma cells cultured from pleural effusion. We reviewed 12 cases of ectopic amylase-producing multiple myeloma. All the cases except one have been reported from Japan, and hyperamylasemia in these cases was detected at diagnosis or during course of the illness. Moreover, cytogenetic analysis of myeloma cells of previous reports revealed structural abnormalities including chromosome 1, near the amylase gene locus. This case also showed t(1;10)(q21?;q26) by examination of 8 metaphase derived from bone marrow. These observations suggested that ectopic amylase production was induced by irradiation to the plasmacytoma of thoracic wall.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 36 (10), 1175-1181, 1995

    The Japanese Society of Hematology

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