Diffuse large B-cell lymphoma expressing surface immunoglobulin heavy chain (Igα) and lacking light chains

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  • ANDO Miki
    Department of Hematology, Juntendo University School of Medicine
  • ISOBE Yasushi
    Department of Hematology, Juntendo University School of Medicine
  • SASAKI Makoto
    Department of Hematology, Juntendo University School of Medicine
  • SUGIMOTO Koichi
    Department of Hematology, Juntendo University School of Medicine
  • ANDO Jun
    Department of Hematology, Juntendo University School of Medicine
  • OSHIMI Kazuo
    Department of Hematology, Juntendo University School of Medicine

Bibliographic Information

Other Title
  • 免疫グロブリンH鎖(Igα)を細胞表面に発現し，L鎖の発現を認めないびまん性大細胞型B細胞リンパ腫
  • 症例 免疫グロブリンH鎖(Igα)を細胞表面に発現し,L鎖の発現を認めないびまん性大細胞型B細胞リンパ腫
  • ショウレイ メンエキ グロブリン H サ Ig アルファ オ サイボウ ヒョウメン ニ ハツゲン シ L サ ノ ハツゲン オ ミトメ ナ イビマンセイ ダイ サイボウガタ B サイボウ リンパ シュ

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Abstract

A 59-year-old woman with goiter complained of nausea, vomiting and weight loss in April 2000. She underwent an endoscopic examination and was admitted to our hospital because gastric biopsy specimens revealed that she had diffuse large B-cell lymphoma. A thyroid biopsy also detected the diffuse infiltration of lymphoma cells, which were positive for CD19, CD20, CD38 and HLA-DR. Although the cells expressed surface immunoglobulin α chain, they lacked expressions of the κ and λ light chains. Chromosomal analysis of the thyroid cells showed 47, XX, t(2;3)(q31;q13), +3, t(8;22)(q24;q11). After five courses of biweekly CHOP chemotherapy, she received autologous peripheral blood stem cell transplantation in October 2000. Currently, she has maintained complete remission for more than 4 years.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 46 (7), 492-495, 2005

    The Japanese Society of Hematology

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