書誌事項
- タイトル別名
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- Vinca-Alkaloid Slow Infusion Therapy in Refractory Idiopathic Thrombocytopenic Purpura
- ナンジセイ ITP ニ タイスル Vinca Alkaloid カンソク ジョ
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抄録
Vinca-alcaloid (V-A) was given in slow infusion to six adult patients with refractory idiopathic thrombocytopenic purpura (ITP), including 5 were unresponsive to glucocorticoids, and one who was unresponsive to danazol. Vincristine, 0.02 mg/kg or vinblastine 0.1 mg/kg, was dissolved in 500 ml of isotonic saline and infused intravenouslty over 6 hours.<br>The mean platelet count of the patients on study was 2.18±1.3 (×104/mm3), which rose to 6.8±3.7 (×104/mm3) to 7.8±4.4 (×104/mm3), to 11.2±6.6 (×104/mm3) and to 14.9±5.1 (×104/mm3), 1, 4, 8 and 15 weeks after the begnining of therapy, respectively. Side effects, including mild neuropathy, constipation, alopecia, and leukopenia were common on V-A slow infusion, but were decreased by the reduction of dose of V-A, except severe neuropathy in one patient who needed the cessation of therapy.<br>These findings indicated that Vinca-alkaloid slow infusion therapy is effective and tolerable to the patients with refractory ITP.
収録刊行物
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- 臨床血液
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臨床血液 28 (2), 194-198, 1987
一般社団法人 日本血液学会
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詳細情報 詳細情報について
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- CRID
- 1390001205032581376
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- NII論文ID
- 130004499117
- 40003771971
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- NII書誌ID
- AN00252940
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- COI
- 1:STN:280:BiiC1MbislM%3D
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- ISSN
- 18820824
- 04851439
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- NDL書誌ID
- 3123767
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- PubMed
- 3573337
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可