書誌事項
- タイトル別名
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- A Case of Acute Myeloblastic Leukemia with Auer's Bodies in Mature Neutrophils
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抄録
A 14-year-old male was admitted on June 3, 1982 because of pyrexia and nosebleed. Physical examination revealed neither lymphadenopathy nor hepatosplenomegaly.<br>Laboratory examination showed RBC 137×104/cmm, hemoglobin 4.9 g/dl, Ht 13.5%, platelets 1.1×104/cmm, and WBC 6,600/cmm with 38.5% myeloblasts and 3% promyelocytes. Auer's bodies were observed in immature leukemic cells and in mature neutrophils with pseudo-Pelger-Huët's anomaly. Neutrophil alkaline phosphatase (NAP) activity was low. A sternal marrow aspiration disclosed hypercellular marrow (nucleated cell count, 272,000/cmm) with 64.9% myeloblasts and 1.9% promyelocytes. A diagnosis of acute myeloblastic leukemia (M2 in FAB classification) was made. A complete remission was obtained by combination chemotherapy with daunomycin, Ara-C, BH-AC and prednisolone. Auer's bodies in both blast cells and mature neutrophils disappeared and NAP activity rose to normal level after complete remission. In this case, neutrophils with Auer's bodies might orignate from immature leukemic cells. It is suggested that leukemic cells differentiate to mature neutrophils in some case of acute myeloid leukemia.
収録刊行物
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- 臨床血液
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臨床血液 25 (3), 372-376, 1984
一般社団法人 日本血液学会