Infliximab therapy for Crohn's-like gastrointestinal lesions after allogeneic bone marrow transplantation

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  • 同種移植後に生じたクローン病様消化管病変に対するinfliximabの効果
  • 症例報告 同種移植後に生じたクローン病様消化管病変に対するinfliximabの効果
  • ショウレイ ホウコク ドウシュ イショク ゴ ニ ショウジタ クローンビョウ ヨウ ショウカカン ビョウヘン ニ タイスル infliximab ノ コウカ

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A 45-year-old man was diagnosed with t(8;21) positive acute myelogenous leukemia and failed to achieve complete remission (CR) after the first induction chemotherapy. He was then treated with high-dose cytarabine and achieved CR. Molecular relapse was detected during post-remission therapy and he underwent myeloablative bone marrow transplantation from his HLA-matched sibling donor. One year after transplantation, he developed an intractable anal fistula during treatment of chronic GVHD. Colonoscopy showed longitudinal ulcers and cobblestone appearance, and histopathological examination revealed non-caseating epithelioid granuloma. According to these findings, he was diagnosed with Crohn's-like chronic gastrointestinal inflammatory disease. He was treated with enteral nutrition, mesalazine and dose re-escalation of cyclosporine, but these therapies were not effective. Therefore, we decided to treat him with infliximab. After starting treatment with infliximab, his abdominal symptoms and the anal fistula showed prompt improvement. There are few reports regarding the efficacy of infliximab for gastrointestinal chronic GVHD. Our experience suggests that infliximab could be useful for the treatment of Crohn's-like gastrointestinal inflammatory disease.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 56 (12), 2452-2455, 2015

    The Japanese Society of Hematology

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