Acquisition of IgH/CCND1 translocation during the natural disease course in a patient with chronic lymphocytic leukemia

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  • ARAI Kosuke
    Department of Hematology, Ome Municipal General Hospital
  • TAKAGI Fumisato
    Department of Hematology, Ome Municipal General Hospital
  • SONOKAWA Saeko
    Department of Hematology, Ome Municipal General Hospital
  • SUZUKI Sayaka
    Department of Hematology, Ome Municipal General Hospital
  • ITO Eisaku
    Department of Pathology, Ome Municipal General Hospital
  • TAKEUCHI Kengo
    Pathology Project for Molecular Targets, The Cancer Institute of Japanese Foundation for Cancer Research Division of Pathology, the Cancer Institute Hospital of Japanese Foundation for Cancer Research
  • KUMAGAI Takashi
    Department of Hematology, Ome Municipal General Hospital

Bibliographic Information

Other Title
  • 自然経過中にIgH/CCND1転座が付加された慢性リンパ性白血病
  • 症例報告 第6回日本血液学会関東甲信越地方会 優秀演題 自然経過中にIgH/CCND1転座が付加された慢性リンパ性白血病
  • ショウレイ ホウコク ダイ6カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ ユウシュウ エンダイ シゼン ケイカ チュウ ニ IgH/CCND1テンザ ガ フカ サレタ マンセイ リンパセイ ハッケツビョウ

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Abstract

<p>A 69-year-old man visited a doctor because of systemic lymphadenopathy. Peripheral blood examination revealed leukocytosis, anemia, and decreased platelet count (WBC, 103,060/µl; lymph, 92.2%; Hb, 8.9 g/dl; and Plt, 4.1×104/µl). Bone marrow biopsy revealed that approximately 70% of nucleated cells were small, mature lymphoid cells with positive immunostaining for CD5, CD20, and CD23. He was diagnosed with chronic lymphocytic leukemia (CLL). The IgH/CCND1 translocation and ATM locus loss in 20% and 95% peripheral cells, respectively, were detected by fluorescence in situ hybridization. Immunostaining revealed that cyclin D1 was positive in approximately 30% bone marrow cells. As the positive rate of CCND1 fusion signal was low, the diagnosis of mantle cell lymphoma was excluded. In contrast, signals of ATM locus deletion were detected in most tumor cells. Therefore, we assessed that IgH/CCND1 translocations occurred during the natural clinical course of CLL with ATM locus deletion from the onset of disease. The secondary IgH/CCND1 translocation in CLL is rare, and all reported cases with such translocations received treatments with alkylating agents. This is the first report regarding secondary IgH/CCND1 translocation during the natural clinical course of CLL and may provide insights into CLL pathogenesis.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 59 (1), 51-57, 2018

    The Japanese Society of Hematology

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