Effect of Verapamil on the Transmural Energy Metabolism in the Isoproterenol-induced Myocardinal Lesion
-
- HIGUCHI Makie
- Department of Pharmacology, Kumamoto University Medical School
-
- TAKENAKA Fumio
- Department of Pharmacology, Kumamoto University Medical School
書誌事項
- タイトル別名
-
- Effect of Verapamil on the Transmural Energy Metabolism in the Isoproterenol-induced Myocardial Lesion
- Effect of Verapamil on the Transmural E
この論文をさがす
抄録
The effect of verapamil on the isoproterenol(ISO)-induced transmural metabolic lesion in the left ventricular wall was investigated in the rat heart. The treatment with ISO 2.5mg/Kg s.c. on 2 consecutive days resulted in significant decreases of creatine phosphate in the subendocardium(ENDO) and of adenosine triphosphate in the ENDO and the subepicardium. On the other hand, inorganic phosphate(Pi) and lactate (LA) were increased in both layers. These changes were more prominent in the ENDO. Pretreatment with verapamil 25mg/Kg s.c. prevented the reduction of high energy phosphate compounds and the increases of Pi and LA in both layers by ISO.
収録刊行物
-
- Japanese Heart Journal
-
Japanese Heart Journal 19 (6), 913-917, 1978
International Heart Journal刊行会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205037662464
-
- NII論文ID
- 130000762465
-
- NII書誌ID
- AA00690786
-
- ISSN
- 1348673X
- 00214868
-
- NDL書誌ID
- 2074108
-
- PubMed
- 750673
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可