Hypotensive action and increased plasma renin activity by Ca2+ anatagonist(Nifedipine)in hypertensive patients

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  • AOKI Kyuzo
    Second Department of Medicine, Nagoya City University Medical School
  • YOSHIDA Tadashi
    Second Department of Medicine, Nagoya City University Medical School
  • KATO Setsuko
    Second Department of Medicine, Nagoya City University Medical School
  • TAZUMI Kazuhiro
    Second Department of Medicine, Nagoya City University Medical School
  • SATO Iwao
    Second Department of Medicine, Nagoya City University Medical School
  • TAKIKAWA Kiyoharu
    Second Department of Medicine, Nagoya City University Medical School
  • HOTTA Ken
    First Department of Physiology, Nagoya City University Medical School

書誌事項

タイトル別名
  • Hypotensive Action and Increased Plasma Renin Activity by Ca<sup>2+</sup> Antagonist (Nifedipine) in Hypertensive Patients
  • Hypotensive action and increased plasma
  • Hypertensive action and increased plasma renin activity by Ca antagonist (nifedipine) in hypertensive patients

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The Ca2+ antagonistic coronary vasodilator, Nifedipine, was sublingually administered by a dose of 30mg to 19 patients with hypertension.<br>Blood pressure of patients with essential hypertension (n=14) decreased from 177±24 to 123±13mmHg systolic and from 108±12 to 80±11mmHg diastolic (mean±SD) (p<0.01). Heart rate increased significantly from 73±11 to 85±10 beats/min (p<0.01). Plasma renin activity (PRA) increased significantly from 0.73±0.62 to 1.50±1.02ng/ml/h (p<0.05). The same tendency was observed in malignant and renovascular hypertension. In primary aldosteronism (n=2), blood pressure decreased but PRA did not increase.<br>Hypotensive action and increased plasma renin activity by Ca2+ antagonist, Nifedipine, were clearly demonstrated in patients with hypertension.

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