Effects of bucumolol, a .BETA.-adrenergic blocking agent, and its d-isomer on myocardical infarction produced by coronary artery ligation in rats.

DOI Web Site Web Site PubMed
  • KOIKE Hiroyuki
    Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
  • KUMAKURA Seiji
    Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
  • NISHINO Hiroshi
    Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
  • TAMAOKI Hidetsune
    Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
  • MINATO Sadamasa
    Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.

Bibliographic Information

Other Title
  • Effects of Bucumolol,a β-Adrenergic Blocking Agent,and Its d-Isomer on Myocardial Infarction Produced by Coronary Artery Ligation in Rats
  • Effects of Bucumolol a ベータ Adrenergic B

Search this article

Abstract

Acute ligation of the left coronary artery of rats produced abnormal Q-wave in the electrocardiogram, tachycardia and frequent ventricular fibrillation. Serum CPK level was elevated, reaching a maximum at 3 to 5 hours after ligation and returning to near the pre-ligation level 24 hours later, when CPK activity in the left ventricle markedly decreased. Pretreatment with bucumolol at 2.5mg/Kg s.c. and 5mg/Kg s.c. lessened these changes and increased the survival rate in a dose related manner. d-Bucumolol at 5mg/Kg, on the other hand, increased survival rate primarily by suppressing ventricular fibrillation without any significant effect on other parameters. These results suggest that the membrane stabilizing action does not contribute to protective actions of bucumolol against myocardial ischemia.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top