Comparative Study on Toxicokinetics of Bisphenol A in F344 Rats, Monkeys (Macaca fascicularis), and Chimpanzees (Pan troglodytes)

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  • NEGISHI Takayuki
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo CREST, Japan Science and Technology Corporation
  • TOMINAGA Toshikazu
    Kumamoto Primate Park, Sanwa Kagaku Kenkyusho
  • ISHII Yoshiyuki
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • KYUWA Shigeru
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • HAYASAKA Ikuo
    Kumamoto Primate Park, Sanwa Kagaku Kenkyusho
  • KURODA Yoichiro
    Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience CREST, Japan Science and Technology Corporation
  • YOSHIKAWA Yasuhiro
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo CREST, Japan Science and Technology Corporation

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Abstract

We compared the toxicokinetics of bisphenol A (BPA) among three animal species: rats, cynomolgus monkeys and chimpanzees. Rats and monkeys were administered BPA orally or subcutaneously at 10 or 100 mg/kg body weight, while chimpanzees were administered only 10 mg/kg of BPA. BPA in serum was measured by ELISA. In oral administration of BPA at 10 mg/kg, both Cmax and AUC were rats < chimpanzee < monkeys. In oral administration of BPA at 100 mg/kg, both Cmax and AUC were rats < monkeys. Subcutaneous BPA administrations also revealed similar results, although the values of toxicokinetic parameters in subcutaneous administration were higher than those in oral administration. These results suggest that orally or subcutaneously administered BPA in primates is more easily absorbed than that in rats. We conclude that there are considerable differences in distribution, metabolism, and excretion of BPA between rodents and primates.<br>

Journal

  • Experimental Animals

    Experimental Animals 53 (4), 391-394, 2004

    Japanese Association for Laboratory Animal Science

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