Comparative Study on Toxicokinetics of Bisphenol A in F344 Rats, Monkeys (Macaca fascicularis), and Chimpanzees (Pan troglodytes)
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- NEGISHI Takayuki
- Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo CREST, Japan Science and Technology Corporation
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- TOMINAGA Toshikazu
- Kumamoto Primate Park, Sanwa Kagaku Kenkyusho
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- ISHII Yoshiyuki
- Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- KYUWA Shigeru
- Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- HAYASAKA Ikuo
- Kumamoto Primate Park, Sanwa Kagaku Kenkyusho
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- KURODA Yoichiro
- Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience CREST, Japan Science and Technology Corporation
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- YOSHIKAWA Yasuhiro
- Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo CREST, Japan Science and Technology Corporation
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We compared the toxicokinetics of bisphenol A (BPA) among three animal species: rats, cynomolgus monkeys and chimpanzees. Rats and monkeys were administered BPA orally or subcutaneously at 10 or 100 mg/kg body weight, while chimpanzees were administered only 10 mg/kg of BPA. BPA in serum was measured by ELISA. In oral administration of BPA at 10 mg/kg, both Cmax and AUC were rats < chimpanzee < monkeys. In oral administration of BPA at 100 mg/kg, both Cmax and AUC were rats < monkeys. Subcutaneous BPA administrations also revealed similar results, although the values of toxicokinetic parameters in subcutaneous administration were higher than those in oral administration. These results suggest that orally or subcutaneously administered BPA in primates is more easily absorbed than that in rats. We conclude that there are considerable differences in distribution, metabolism, and excretion of BPA between rodents and primates.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 53 (4), 391-394, 2004
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205041408384
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- NII論文ID
- 10013441800
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 7017111
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- PubMed
- 15297715
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可