Spontaneous Development of Dermatitis in DS-Nh Mice under Specific Pathogen-Free Conditions.
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- WATANABE Akira
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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- TAKEUCHI Mitsuo
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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- NAGATA Masafumi
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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- NAKAMURA Kazuichi
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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- HIRASAWA Tsutomu
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- NAKAO Hiroyuki
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- MAKINO Susumu
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- HARADA Minoru
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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説明
Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions was examined to verify the hypothesis [Exp. Anim. 46: 225-229, 1997] that Stapylococcus aureus (S. aureus) infection is causally associated with the dermatitis. Observation of the mice up to 28 weeks of age indicated that obvious dermatitis does occur under S. aureus-free conditions, though the incidence was low (six of 42 females and two of 90 males). Skin lesions in the absence of this bacterium showed histological changes very similar to those that can be observed under conventional conditions. In addition, hyperproduction of serum IgE was demonstrated in the dermatitis-positive mouse. These findings suggested that the dermatitis is triggered by IgE-mediated allergic reactions.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 52 (1), 77-80, 2003
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205041947264
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- NII論文ID
- 130000068488
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- NII書誌ID
- AA11032321
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- COI
- 1:CAS:528:DC%2BD3sXhvFWjsrw%3D
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 6410593
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- PubMed
- 12638241
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可