Susceptibility Testing for <i>Haemophilus influenzae </i>Isolated from Pediatric Cases during 2004-2008

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  • SAWADA Kyoko
    Division of Clinical Laboratory</sub><sub>, Chiba Childrenʼs Hospital
  • SATO YOKO
    Division of Clinical Laboratory</sub><sub>, Chiba Childrenʼs Hospital
  • ARIMA Masanaga
    Division of Infectious Diseases, Chiba Childrenʼs Hospital
  • HOSHINO Tadashi
    Division of Infectious Diseases, Chiba Childrenʼs Hospital

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Other Title
  • 2004 年から2008 年の小児由来<i>Haemophilus influenzae </i>の抗菌薬感受性に関する検討
  • 2004年から2008年の小児由来Haemophilus influenzaeの抗菌薬感受性に関する検討
  • 2004ネン カラ 2008ネン ノ ショウニ ユライ Haemophilus influenzae ノ コウキンヤク カンジュセイ ニ カンスル ケントウ

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Abstract

We tested for antimicrobial susceptibility of 1,317 clinical isolates of Haemophilus influenzae at a pediatric facility during 2004-2008. The percentage distribution of β-lactamase-non-producing ampicillin (ABPC) sensitive strain (BLNAS) was 47.8％, that of β-lactamase-non-producing ABPC-resistant strain (BLNAR) 32.7％ that of intermediately resistant strain (BLNAI) 8.9％ that of β-lactamase producing ABPC resistant strain (BLPAR) 6.8％ and that of clavulanic acid/amoxicillin resistant strain (BLPACR) 3.7％. BLNAR prevalence was 30％ between 2005 and 2008, increasing slowly. Though reduced susceptibility was seen in most β-lactams, piperacillin and tazobactam/piperacillin showed good susceptibility for H. influenzae. Of 1,317 strains, 83 (6.3％) were serotype b (Hib）. The frequency of Hib was high in sterilized site.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 84 (4), 441-448, 2010

    The Japanese Association for Infectious Diseases

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