書誌事項
- タイトル別名
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- Toxicity Evaluation of Dichloroacetic Acid and Estimation of the Tolerable Daily Intake through Oral Route
- ジクロロ サクサン ノ ドクセイ ヒョウカ ト ケイコウ セッシュ ニ ヨル タイヨウ 1ニチ セッシュリョウ ノ サンテイ
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説明
Recent toxicity information on dichloroacetic acid, one of drinking water disinfectant by-products was evaluated and the tolerable daily intake (TDI) via an oral administration was re-estimated. There are several new informations including metabolism, carcinogenicity and genotoxicity studies since the latest establishment of WHO drinking water quality guideline at 1992 was pronounced.<br>For general toxicity, TDI was calculated as 12.5 μg·kg-1·d-1 from LOAEL of 125 mg·kg-1·d-1, based on neurotoxicity in rats, divided by uncertainty factor of 10000. In addition to the evidence of carcinogenesis in the mouse liver, a recent chronic study demonstrated that dichloroacetic acid is also carcinogenic in the rat liver. Because there is no strong evidence for dichloroacetic acid-induced genotoxicity, TDI for carcinogenesis was considered as 3.6 μg·kg-1·d-1 from carcinogenic NOAEL of 3.6 mg·kg-1·d-1, divided by uncertainty factor of 1000. For reproductive/developmental toxicity, TDI was estimated as 104 μg·kg-1·d-1 from LOAEL of 31.25 mg·kg-1·d-1, based on testicular toxicity in rats, divided by uncertainty factor 300.
収録刊行物
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- 水環境学会誌
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水環境学会誌 22 (10), 821-826, 1999
公益社団法人 日本水環境学会
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詳細情報 詳細情報について
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- CRID
- 1390001205082312448
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- NII論文ID
- 10007470021
- 10008004953
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- NII書誌ID
- AN10372439
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- COI
- 1:CAS:528:DyaK1MXotFOmt7o%3D
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- ISSN
- 18813690
- 09168958
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- NDL書誌ID
- 4880105
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
