Prediction of Left Main or 3-Vessel Disease Using Myocardial Perfusion Reserve on Dynamic Thallium-201 Single-Photon Emission Computed Tomography With a Semiconductor Gamma Camera

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  • Naya Masanao
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
  • Tsutsui Hiroyuki
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

書誌事項

タイトル別名
  • Assessment of Coronary Flow Reserve by Dynamic Single-Photon Emission Computed Tomography
公開日
2015
資源種別
journal article
DOI
  • 10.1253/circj.cj-15-0106
  • 10.1253/circj.cj-14-0932
公開者
一般社団法人 日本循環器学会

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説明

Background:Myocardial perfusion imaging (MPI) may fail to detect balanced ischemia. We evaluated myocardial perfusion reserve (MPR) using Tl dynamic single-photon emission computed tomography (SPECT) and a novel cadmium zinc telluride (CZT) camera for predicting 3-vessel or left main coronary artery disease (CAD).Methods and Results:A total of 55 consecutive patients with suspected CAD underwent SPECT-MPI and coronary angiography. The MPR index was calculated using the standard 2-compartment kinetic model. We analyzed the utility of MPR index, other SPECT findings, and various clinical variables. On multivariate analysis, MPR index and history of previous myocardial infarction (MI) predicted left main and 3-vessel disease. The area under the receiver operating characteristic curve was 0.81 for MPR index, 0.699 for history of previous MI, and 0.86 for MPR index plus history of previous MI. MPR index ≤1.5 yielded the highest diagnostic accuracy. Sensitivity, specificity, and accuracy were 86%, 78%, and 80%, respectively, for MPR index, 64%, 76%, 73% for previous MI, and 57%, 93%, and 84% for MPR index plus history of previous MI.Conclusions:Quantification of MPR using dynamic SPECT and a novel CZT camera may identify balanced ischemia in patients with left main or 3-vessel disease. (Circ J 2015; 79: 623–631)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (3), 515-516, 2015

    一般社団法人 日本循環器学会

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