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- Hisahara Shin
- Department of Pharmacology, Sapporo Medical University, School of Medicine Department of Neurology, Sapporo Medical University, School of Medicine
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- Chiba Susumu
- Department of Neurology, Sapporo Medical University, School of Medicine
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- Matsumoto Hiroyuki
- Department of Neurology, Sapporo Medical University, School of Medicine
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- Horio Yoshiyuki
- Department of Pharmacology, Sapporo Medical University, School of Medicine
書誌事項
- タイトル別名
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- Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: NAD-Dependent Histone Deacetylase SIRT1 (Sir2.ALPHA.)
- NAD Dependent Histone Deacetylase SIRT1 Sir2 アルファ
- Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
この論文をさがす
説明
Sir2 (silent information regulator 2) is an NAD-dependent deacetylase that is broadly conserved from bacteria to humans. It catalyzes a unique deacetylation reaction using NAD, and specific inhibitors and activators of its activity have been discovered. In yeast, Sir2 deacetylates histones and participates in transcription silencing and the suppression of recombination. Sir2 is also implicated in the regulation of aging, because its increased expression extends the lifespan of yeast and nematodes. Mammalian SIRT1 (Sir2α) is a member of the Sir2 family. Recently, SIRT1 was shown to interact with various transcription factors such as p53, forkhead transcription factor (FOXO) family proteins, and MyoD, and to participate in stress tolerance, differentiation, and development.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 98 (3), 200-204, 2005
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205176959744
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- NII論文ID
- 10025728609
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7368799
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- PubMed
- 16006743
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可