Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance
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- TEH Lay Kek
- Pharmacogenomics Centre (PROMISE), Faculty of Pharmacy, Universiti Teknologi MARA
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- BERTILSSON Leif
- Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University, Hospital-Huddinge, Karolinska Institutet
Bibliographic Information
- Other Title
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- Pharmacogenomics of CYP2D6: Molecular genetics
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Description
CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.<br>
Journal
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- Drug Metabolism and Pharmacokinetics
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Drug Metabolism and Pharmacokinetics 27 (1), 55-67, 2012
The Japanese Society for the Study of Xenobiotics
