A Novel Chemoattractant Lectin, Karatoxin, From the Dorsal Spines of the Small Scorpionfish Hypodytes rubripinnis

DOI Web Site 参考文献22件
  • Shinohara Mitsuko
    Depatment of Pharmacology, Osaka Dental University, Japan
  • Nagasaka Kuniko
    Fukae Nagasaka Clinic, Japan
  • Nakagawa Hideyuki
    Depatment of Pharmacology, Osaka Dental University, Japan Department of Environmental Symbiosis, Institute of Socio-Arts and Sciences, The University of Tokushima Graduate School, Japan
  • Edo Kozue
    Department of Environmental Symbiosis, Institute of Socio-Arts and Sciences, The University of Tokushima Graduate School, Japan
  • Sakai Hitomi
    Department of Environmental Symbiosis, Institute of Socio-Arts and Sciences, The University of Tokushima Graduate School, Japan
  • Kato Koji
    Depatment of Pharmacology, Osaka Dental University, Japan
  • Iwaki Futoshi
    Depatment of Pharmacology, Osaka Dental University, Japan
  • Ohura Kiyoshi
    Depatment of Pharmacology, Osaka Dental University, Japan
  • Sakuraba Haruhiko
    Department of Applied Biological Sciences, Kagawa University, Japan

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抄録

A chemoattractant lectin from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis, was isolated using a combination of affinity chromatography techniques. The glycoprotein, with a molecular mass of 110 kDa, is named Karatoxin. Karatoxin caused agglutination of rabbit erythrocytes. This agglutination was effectively inhibited by D-mannose. In addition, Karatoxin exhibited not only mitogenic activity in the presence of murine splenocytes, but also chemotactic activity in the presence of guinea-pig neutrophils and macrophages. Thus, Karatoxin appears to be a novel chemoattractant lectin. These results suggest that the redfin velvetfish Hypodytes rubripinnis may be a novel source of biologically active substances.

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