Colorectal cancer as a life style-related disease: from carcinogenesis to medical treatment

  • Takahashi Hirokazu
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Yoneda Kyoko
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Tomimoto Ayako
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Endo Hiroki
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Fujisawa Toshio
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Iida Hiroshi
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Mawatari Hironori
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Nozaki Yuichi
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Ikeda Tamon
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Akiyama Tomoyuki
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Yoneda Masato
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Inamori Masahiko
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Abe Yasunobu
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Saito Satoru
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Nakajima Atsushi
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
  • Nakagama Hitoshi
    Biochemistry Division, National Cancer Center Research Institute, Japan

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タイトル別名
  • Life Style-Related Diseases of the Digestive System: Colorectal Cancer as a Life Style-Related Disease: from Carcinogenesis to Medical Treatment

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Life style-related diseases are associated with an increased risk of colorectal cancer (CRC). Recently, an association has been demonstrated between obesity and CRC. CRC has been associated with markers of insulin or glucose control, and insulin resistance might be the unifying mechanism by which several risk factors affect colorectal carcinogenesis. We evaluated the association between the number of aberrant crypt foci (ACF) and obesity, insulin resistance, hyperlipidemia, and other factors of life style-related disease. As a result, age, body mass index (BMI), waist circumference, and visceral fat obesity were significantly associated with the number of ACF. These results suggest that visceral fat obesity is an important target for CRC prevention. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor superfamily and is highly expressed in CRC. PPARγ ligand administration for 1 to 8 months significantly reduced the number of ACF in human subjects. PPARγ ligand is a promising candidate as a chemopreventive agent. Further investigation is needed to elucidate these mechanisms.<br>

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