Evidence for Major Histocompatibility Linked and Non-Linked Genetic Regulation of Immune Response in Chickens

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  • 鶏の免疫応答における組織適合性座位との連関遺伝ならびに非連関遺伝
  • ニワトリ ノ メンエキ オウトウ ニ オケル ソシキ テキゴウセイザイ ト ノ

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Abstract

The immune response of chickens to the dinitrophenyl group (DNP) conjugated to chicken gamma globulin (CGG) and DNP-bovine serum albumin (BSA) has been examined. Two lines, H and L, selected for high and low competences of graftversus-host reaction (GVHR) were used. Immune responses were controlled not only by the gene linked to the B complex, the major histocompatibility complex (MHC) in chickens, but also by non-MHC-linked gene (s). It was found that there was no difference in relative responsiveness depending upon the carrier molecules conjugated to hapten. The relative immune responsiveness was B11/B11⟩B9/B11⟩B9/B9 and H⟩L in both anti-DNP and anti-BSA antibodies. It seemed that the action of the MHC-linked gene was additive or incomplete dominant. The results suggest that the relative magnitude of antibody responsiveness and of splenomegaly competence in GVHR are controlled under a common mechanism.

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