書誌事項
- タイトル別名
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- Influences of Modified Borage Oil Rich in γ-Linolenic Acid and Linseed Oil Rich in α-Linolenic Acid on MRL/lpr Mice
- カイシツ シタ ガンマ リノレンサン コウガンユウ ボラージユ ト アルファ リノレンサン コウガンユウ アマニユ ガ ジコ メンエキ シッカンイハッショウ マウス MRL lpr ニ オヨボス エイキョウ
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Effects of omega 3 and omega 6 unsaturated fatty acids on the autoimmune factors in MRL/lpr prone mice were investigated. Linseed oil was used as alpha-linolenic acid-rich oil (about 56%). Gamma-linolenic acid-rich oil containing the same amount as alpha-linolenic acid in linseed oil was prepared from borage oil. These oils and soybean oil were fed to the mice from 8 weeks old to 20 weeks old. Body weight of gamma-linolenic acid-rich oil group was significantly lower than that of alpha linolenic acid-rich oil group. Spleen swelling was suppressed by the administration of alpha and gamma-linolenic acids-rich oils, compared with soybean oil group. The suppression of the production of autoantibody and the decrease in urine albumin concentration were also observed. The administration of alpha-linolenic acid reduced the production of TNF-alpha, IL-1beta, and IL-6. Gamma-linolenic acid group gave the intermediate score. The production of IL-18 showed the highest value in soybean oil group.
収録刊行物
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- 日本食品化学学会誌
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日本食品化学学会誌 13 (3), 125-130, 2006
日本食品化学学会
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詳細情報 詳細情報について
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- CRID
- 1390001205195232256
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- NII論文ID
- 110007367344
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- NII書誌ID
- AA11666400
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- ISSN
- 21896445
- 13412094
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- NDL書誌ID
- 8666316
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可