Effect of capsaicin and <i>N</i>-docosahexaenoyl-vanillylamide on growth of taxol-tolerant HeLa cells

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  • Capsaicinおよび<i>N</i>-docosahexaenoyl-vanillylamideのtaxol耐性HeLa細胞の増殖に及ぼす影響
  • CapsaicinおよびN-docosahexaenoyl-vanillylamideのtaxol耐性HeLa細胞の増殖に及ぼす影響
  • Capsaicin オヨビ N docosahexaenoyl vanillylamide ノ taxol タイセイ HeLa サイボウ ノ ゾウショク ニ オヨボス エイキョウ

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Abstract

There are few effective clinical studies to inhibit the growth of multidrug resistance tumor cells. We have been interested in the physiological actions of capsaicin (CAP), the pungent ingredient in hot chilli peppers, and polyunsaturated fatty acids, for example docosahexaenoic acid (DHA), extracted from fish oil. In this study, we synthesized a new vanillylamide derivative, N-docosahexaenoyl-vanillylamide (dohevanil), to investigate the inhibitory effect of dohevanil on growth of HeLa cells and taxol-tolerant HeLa cells. As a result, dohevanil has more potent inhibitory effect than CAP for both taxol-sensitive HeLa cells and taxol-tolerant HeLa cells. Particularly, the simultaneous addition of dohevanil and taxol more strongly induced cell death of taxol-tolerant HeLa cells. There results obtained in this study suggest that dohevanil has stronger inhibitory effect than CAP for the multidrug resistance cells.

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