Chicken Ovotransferrin Variants OTF[B] and OTF[C] Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity

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  • Kinoshita Keiji
    Avian Bioscience Research Center, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
  • Myint Si Lhyam
    United-graduate School of Agriculture, Kagoshima University, Japan
  • Shimogiri Takeshi
    Faculty of Agriculture, Kagoshima University, Japan
  • Ibrahim Hisham R.
    Faculty of Agriculture, Kagoshima University, Japan
  • Kawabe Kotaro
    Natural Science Centre for Research and Education, Kagoshima University, Japan
  • Okamoto Shin
    Faculty of Agriculture, Kagoshima University, Japan
  • Lee Yen-Pei
    Faculty of Animal Science, National Chung Hsing University, Taiwan
  • Matsuda Yoichi
    Avian Bioscience Research Center, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
  • Maeda Yoshizane
    Faculty of Agriculture, Kagoshima University, Japan

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タイトル別名
  • Chicken Ovotransferrin Variants OTF<sup>B</sup> and OTF<sup>C</sup> Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity

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<p>Chicken egg white ovotransferrin (OTF) has been reported to exist in three electrophoretic variants (OTFA, OTFB and OTFC). In this report, we identified a causal polymorphism between the OTFB and OTFC variants in Japanese and Taiwanese native chickens and compared the antibacterial activity between these two variants. The cDNA sequence analyses from Satsumadori oviducts revealed that three non-synonymous SNPs T1809G (Ser52Ala), A2258G (Ile96Val) and G7823A (Asp500Asn) corresponded to the OTF electrophoretic phenotypes. Of the three SNPs, the G7823A mutation perfectly corresponded to the electrophoretic phenotypes OTFB (G/G, Asp500Asp), OTFB/C (G/A, Asp500Asn) and OTFC (A/A, Asn500Asn) in three chicken populations. The variants OTFB and OTFC exhibited similar antibacterial potency against Gram-positive and Gram-negative bacteria. This study provides, for the first time, molecular information on polymorphism of OTFB and OTFC variants of chicken ovotransferrin and its effect on the antimicrobial activity of the respective variants.</p>

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