Chicken Ovotransferrin Variants OTF[B] and OTF[C] Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity
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- Kinoshita Keiji
- Avian Bioscience Research Center, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
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- Myint Si Lhyam
- United-graduate School of Agriculture, Kagoshima University, Japan
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- Shimogiri Takeshi
- Faculty of Agriculture, Kagoshima University, Japan
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- Ibrahim Hisham R.
- Faculty of Agriculture, Kagoshima University, Japan
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- Kawabe Kotaro
- Natural Science Centre for Research and Education, Kagoshima University, Japan
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- Okamoto Shin
- Faculty of Agriculture, Kagoshima University, Japan
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- Lee Yen-Pei
- Faculty of Animal Science, National Chung Hsing University, Taiwan
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- Matsuda Yoichi
- Avian Bioscience Research Center, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
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- Maeda Yoshizane
- Faculty of Agriculture, Kagoshima University, Japan
書誌事項
- タイトル別名
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- Chicken Ovotransferrin Variants OTF<sup>B</sup> and OTF<sup>C</sup> Harboring Substitution of GAT (Asp) to AAT (Asn) in the Codon 500 and their Antimicrobial Activity
この論文をさがす
抄録
<p>Chicken egg white ovotransferrin (OTF) has been reported to exist in three electrophoretic variants (OTFA, OTFB and OTFC). In this report, we identified a causal polymorphism between the OTFB and OTFC variants in Japanese and Taiwanese native chickens and compared the antibacterial activity between these two variants. The cDNA sequence analyses from Satsumadori oviducts revealed that three non-synonymous SNPs T1809G (Ser52Ala), A2258G (Ile96Val) and G7823A (Asp500Asn) corresponded to the OTF electrophoretic phenotypes. Of the three SNPs, the G7823A mutation perfectly corresponded to the electrophoretic phenotypes OTFB (G/G, Asp500Asp), OTFB/C (G/A, Asp500Asn) and OTFC (A/A, Asn500Asn) in three chicken populations. The variants OTFB and OTFC exhibited similar antibacterial potency against Gram-positive and Gram-negative bacteria. This study provides, for the first time, molecular information on polymorphism of OTFB and OTFC variants of chicken ovotransferrin and its effect on the antimicrobial activity of the respective variants.</p>
収録刊行物
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- The Journal of Poultry Science
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The Journal of Poultry Science 53 (4), 257-263, 2016
日本家禽学会
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詳細情報 詳細情報について
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- CRID
- 1390001205208156032
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- NII論文ID
- 130005433120
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- NII書誌ID
- AA11564513
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- ISSN
- 13490486
- 13467395
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- NDL書誌ID
- 027670116
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可