• 斯波 久二雄
    Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
  • 金子 秀雄
    Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
  • 角田 紀子
    Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
  • 吉野 浩美
    Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
  • 射場 一彦
    Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
  • 中塚 巌
    Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
  • 吉武 彬
    Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
  • 山田 宏彦
    Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.

書誌事項

タイトル別名
  • Metabolism of Diethofencarb in Rats
  • Diethofencarbのラットにおける代謝〔英文〕
  • Diethofencarb ノ ラット ニ オケル タイシャ エイブン

この論文をさがす

抄録

Metabolic fates of diethofencarb (isopropyl 3, 4-diethoxycarbanilate) were examined in male and female rats. After single oral doses of [phenyl-14C]diethofencarb at 10mg/kg or 300mg/kg, most of the dosed 14C was recovered in the urine and feces within 48hr after dosing. The total 14C-recovery ranged from 99 to 100% of the dose during 7 days after administration with the 14C urinary excretion being 80 to 88% of the dose. 14C-Levels in the blood and various tissues reached maxima within 0.5hr after administration and decreased rapidly thereafter with biological half-lives of 12 to 35hr. 14C-Tissue residues were substantially low. The residue levels were the highest in the liver (0.05-0.07 and 1.70-2.22ppm for the low and high doses, respectively). Total tissue residues of 14C on the 7th day after dosing were less than 0.2% of the dose. Major metabolic reactions of diethofencarb were (1) de-ethylation of the 4-ethoxy group, (2) cleavage of the carbamate linkage, (3) acetylation of the amino group and (4) conjugation of the resultant phenols with sulfuric acid or glucuronic acid. A major metabolite in the urine was the sulfate of isopropyl 3-ethoxy-4-hydroxycarbanilate (30.0-48.7% of the dose). No marked sex-related difference was observed in the metabolism of diethofencarb.

収録刊行物

被引用文献 (1)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ