新規殺虫剤ピリダリルの昆虫由来培養細胞Sf9に対する毒性

DOI NDLデジタルコレクション 日本農学文献記事索引 Web Site Web Site 被引用文献3件 参考文献26件
  • Saito Shigeru
    Agricultural Chemicals Research Laboratory, Sumitomo Chemical Co., Ltd.
  • Sakamoto Noriyasu
    Agricultural Chemicals Research Laboratory, Sumitomo Chemical Co., Ltd.
  • Umeda Kimitoshi
    Agricultural Chemicals Research Laboratory, Sumitomo Chemical Co., Ltd.

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タイトル別名
  • Effects of Pyridalyl, a Novel Insecticidal Agent, on Cultured Sf9 Cells

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The effect of pyridalyl on cultured Sf9 cells was compared with that of various known cytotoxic and non-cytotoxic substances. Cell growth was significantly inhibited by the cytotoxic substances at 10 μM, but not significantly inhibited by the non-cytotoxic substances. Pyridalyl clearly inhibited the growth of cells at a concentration of 0.01 μM. Analogues of pyridalyl with insecticidal activity also inhibited cell growth, but those without insecticidal activity did not have significant effects. The test system was considered valid and the cytotoxicity of pyridalyl in Sf9 cells reflects its insecticidal action at least in part. Pyridalyl did not, however, affect mitochondrial respiration, which is the most likely cause of the cytotoxicity. © Pesticide Science Society of Japan

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