Production of Acrylamide via the Long-Term Incubation of Asparagine and Reducing Sugar Solutions at 37°C

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  • アスパラギンと還元糖溶液の 37℃ での長期間インキュベーションによるアクリルアミドの生成
  • アスパラギン ト カンゲン トウ ヨウエキ ノ 37℃ デ ノ チョウキカン インキュベーション ニ ヨル アクリルアミド ノ セイセイ

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Abstract

In this study, we examined whether AA can be produced in Fru + Asn and Glc + Asn solutions that are incubated at 37°C for a long time. Acrylamide was observed in both solutions at pH 7.4 and pH 12.0. The Fru + Asn group became a deeper brown, but had a lower AA production rate than the Glc + Asn group at each pH. This suggests the presence of an acrylamide production pathway different from those in related high-temperature processes. Moreover, the generation of acrylamide at pH 7.4 in the Glc + Asn solution at 37°C suggests that acrylamide can be produced as an advanced glycation end product in the living body.<br>

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