A Case of Plasmocytosis Circumorificialis on the Lower Lip of a Patient with Plasma Cell Leukemia

DOI 3 Citations 22 References
  • JINBU Yoshinori
    Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University
  • KAWA Rumi
    Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University
  • YAMASHITA Masako
    Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University
  • KUSAMA Mikio
    Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University
  • DEMITSU Toshio
    Department of Dermatology, Jichi Medical University Saitama Medical Center

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  • 形質細胞性白血病患者の下唇に生じた開口部形質細胞症の1例

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Plasmocytosis circumorificialis (PC) is a rare inflammatory mucosal disease histologically characterized by dense plasma cell infiltrates. A 73-year-old woman presented with ulceration on the lower lip. She had been receiving cancer chemotherapy for plasma cell leukemia (IgG, κ type). The ulcer located on the center of the lower labial mucosa was 10 × 7 mm in size with an irregular shape. Biopsy was performed under a clinical diagnosis of leukemia cell infiltration. Histopathologically, inflammatory cell infiltration mainly comprising plasma cells was observed, but immunohistochemical analysis showed a mixture of κ chain-positive and λ chain -positive cells. The ulcer completely epithelialized after biopsy. Final diagnosis was PC of the lower lip.

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