わが国における中咽頭癌HPV感染の現状

DOI 参考文献6件

書誌事項

タイトル別名
  • Current status of human papilloma virus infection in oropharynx cancer
  • —A multicenter study in Japan
  • ―多施設共同研究から―
公開日
2012
DOI
  • 10.5981/jjhnc.38.390
公開者
日本頭頸部癌学会

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説明

The recent increase in incidence of oropharyngeal cancer in the USA and northern Europe has been attributed to human papillomavirus (HPV) infection. HPV causes an epidemiologically and clinically distinct form of oropharyngeal squamous cell carcinoma (OPSCC). The prevalence of HPV in Japanese patients with OPSCC is not clear. The Japanese Cooperative Study Group for Basic Research in Head and Neck Cancer (JCSG-BRHNC) performed a prospective study to clarify the prevalence and genotype distribution of HPV in OPSCC in Japan. Patients without prior treatments were registered from May 2009 to March 2011 and tissue samples were collected from 20 institutes. OPSCC tissue samples from 158 patients were tested using polymerase chain reaction (PCR) and Hybrid Capture II (HC2). Non-cancerous tissues from 54 patients with chronic tonsillitis or tonsil hypertrophy were also examined as controls. Results: HPV was detected in 79 (50.3%) of 157 patients and 1 of 112 control patients by PCR. HPV genotype distributions revealed HPV16 in 70 cases (88.6%). In histological features, cases with low differentiation type were dominant in HPV-positive OPSCC (p = 0.0175). The sub-sites of tumor were lateral wall (tonsil) in 73(92.4%) for HPV-positive patients and 44 (56.4%) for HPV-negative patients (p < 0.0001). The ratio of stage IV was larger in the HPV-positive patients than in the HPV-negative patients. The ratios of non-smoker and non-drinker OPSCC patients were also was larger in the HPV-positive patients than in the HPV-negative patients. Overall survival was better in HPV-positive than HPV-negative patients with stage III or IV OPSCC treated with CRT or surgery. HPV detection using HC2 using oral brushing samples revealed that sensitivity and specificity were 93.7% and 96.2%, respectively. We clarified the prevalence of HPV of OPSCC in Japanese. The clinical features and prognosis were similar to the data reported in the USA.

収録刊行物

  • 頭頸部癌

    頭頸部癌 38 (4), 390-393, 2012

    日本頭頸部癌学会

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