Clinical characteristics and long-term outcome of hypertrophic cardiomyopathy. Results from the Aichi hypertrophic cardiomyopathy (AHC) registry
-
- Yoshinaga Masataka
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital
-
- Yoshikawa Daiji
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital Department of Cardiology, Nagoya University Graduate School of Medicine
-
- Ishii Hideki
- Department of Cardiology, Nagoya University Graduate School of Medicine
-
- Hirashiki Akihiro
- Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine
-
- Okumura Takahiro
- Department of Cardiology, Nagoya University Graduate School of Medicine
-
- Kubota Aki
- Department of Hospital Pharmacy, Nagoya University Hospital
-
- Sakai Shinichi
- Department of Cardiology, Kainan Hospital
-
- Harada Ken
- Department of Cardiology, Chubu Rosai Hospital
-
- Somura Fuji
- Department of Cardiology, Nagoya Central Hospital
-
- Mizuno Tomofumi
- Department of Cardiology, Aichi Medical University
-
- Fujiwara Wakaya
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital
-
- Yokoi Hiroatsu
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital
-
- Hayashi Mutsuharu
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital Department of Cardiology, Nagoya University Graduate School of Medicine
-
- Ishii Junichi
- Department of Cardiology, Fujita Health University Hospital
-
- Ozaki Yukio
- Department of Cardiology, Fujita Health University Hospital
-
- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
-
- Yoshida Yukihiko
- Department of Cardiology, Cardiovascular Center, Nagoya Daini Red Cross Hospital
-
- Amano Tetsuya
- Department of Cardiology, Aichi Medical University
-
- Izawa Hideo
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital
書誌事項
- タイトル別名
-
- Clinical Characteristics and Long-Term Outcomes of Hypertrophic Cardiomyopathy
- Results from the Aichi Hypertrophic Cardiomyopathy (AHC) Registry
この論文をさがす
説明
Hypertrophic cardiomyopathy (HCM) has various morphological and clinical features. A decade has passed since the previous survey of the epidemiological and clinical characteristics of Japanese HCM patients. The Aichi Hypertrophic Cardiomyopathy (AHC) Registry is based on a prospective multicenter observational study of HCM patients. The clinical characteristics of 42 ambulant HCM patients followed up for up to 5 years were investigated. The primary endpoint was major adverse cardiac events (MACE), defined as death, non-fatal stroke, admission due to congestive heart failure (CHF), or episodes of sustained ventricular tachycardia/fibrillation. The MACE-free survival during the 5-year follow-up period was 76% according to Kaplan–Meier analysis. HCM-related death occurred in 3 (7%) patients and SCD occurred in 2 (5%) patients. Additionally, 3 (7%) patients were admitted to the hospital due to CHF. Meanwhile, sustained VT was detected in one (2%) of the patients who received ICD implantation and subsequently terminated with antitachycardia pacing using an ICD. The patients with HCM exhibiting left ventricular outflow obstruction (HOCM) had a slightly lower MACE-free survival rate than those with neither HOCM nor dilated-HCM (dHCM) (71% versus 81%, log-rank P = 0.581). Furthermore, the patients with dHCM demonstrated a significantly lower MACE-free survival rate than those with neither HOCM nor dHCM (33% versus 81%, log-rank P = 0.029). In the AHC Registry targeting current Japanese HCM patients, we demonstrated that many HCM patients continue to suffer from MACE despite the development of various treatments for HCM.
収録刊行物
-
- International Heart Journal
-
International Heart Journal 56 (4), 415-420, 2015
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
