Effects of the T/L-type Calcium Channel Blocker Benidipine on Albuminuria and Plasma Aldosterone Concentration
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- Tani Shigemasa
- Department of Cardiology, Surugadai Nihon University Hospital Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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- Takahashi Atsuhiko
- Department of Cardiology, Surugadai Nihon University Hospital Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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- Nagao Ken
- Department of Cardiology, Surugadai Nihon University Hospital Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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- Hirayama Atsushi
- Division of Cardiology, Department of Medicine, Nihon University School of Medicine
書誌事項
- タイトル別名
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- A Pilot Study Involving Switching from L-type Calcium Channel Blockers to Benidipine
- 公開日
- 2014
- 資源種別
- journal article
- DOI
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- 10.1536/ihj.14-034
- 公開者
- 一般社団法人 インターナショナル・ハート・ジャーナル刊行会
この論文をさがす
説明
Albuminuria and a high plasma aldosterone concentration (PAC) are prognosis factors predicting a poor outcome for cardiovascular disease. We examined here the effects of benidipine, a T/L-type calcium channel blocker (CCB), on albuminuria and PAC.<br>Thirty-one patients with essential hypertension who received an L-type CCB and achieved the target blood pressure (BP) indicated by the Treatment Guidelines of the Japan Society of Hypertension (JSH2009) were investigated. The Ltype CCB under treatment was switched to benidipine at a dose in which equivalent BP reduction was expected. BP and estimated glomerular filtration rate at 6 months after switching to benidipine were not significantly different from those at baseline. The urinary-albumin-creatinine ratio (UACR) decreased significantly by 36.9% (P = 0.001). No significant change was observed in plasma renin activity (P = 0.063). The PAC of all patients decreased significantly by 11.8% (P = 0.002). When analyzed by daily doses of benidipine, the PAC appeared to have decreased in patients who received 4 mg per day of benidipine (n = 14), although statistical significance was not reached (P = 0.096). The PAC in patients who received 8 mg per day of benidipine (n =17) was significantly reduced by 13.2% (P = 0.017).<br>In hypertensive patients whose BP is controlled by L-type CCB, switching to the T/L-type CCB benidipine maintained BP control and reduced UACR. In addition, the high dose of benidipine reduced the PAC independent of BP control. These results suggest the T/L-type CCB benidipine may contribute to cardio-renal protection in addition to lowering BP.
収録刊行物
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- International Heart Journal
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International Heart Journal 55 (6), 519-525, 2014
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
