Bio-engineered scaffold with fibroblasts for tracheal regeneration in a rabbit model
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- Okano Wataru
- Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
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- Nomoto Yukio
- Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
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- Kobayashi Ken
- Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
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- Miyake Masao
- Department of Cell Science, Institute of Biomedical Sciences, School of Medicine, Fukushima Medical University, Fukushima, Japan
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- Suzuki Teruhisa
- Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
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- Tada Yasuhiro
- Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
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- Nakamura Tatsuo
- Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
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- Watanabe Mutsumi
- Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
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- Omori Koichi
- Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
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説明
Some patients with malignant or stenotic inflammatory lesions of the trachea require tracheal resection and reconstruction. Conventionally, it is difficult to reconstruct tracheal defects by either end-to-end anastomosis or autologous tissue implantation.<BR>Recently, a few studies on tracheal regeneration using scaffolds have been reported. Collagen-conjugated prothesis have been used for tracheal reconstruction in the clinical application. The problem of this tracheal prosthesis is delay of epithelial regeneration to avoid possible infection.<BR>A bio-engineered scaffold consisted of collagen sponge and polypropylene mesh with fibroblasts was developed for accelerating tracheal regeneration.<BR>The regenerated tracheas were examined by bronchoscopic findings, histological finding and measurement of average thickness of the regenerated trachea. A bio-engineered scaffold was observed to induce more rapid re-epithelization in the large tracheal defect of a rabbit model. This method appears to be feasible for clinical use after further experiments investigating its efficacy and safety.
収録刊行物
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- Inflammation and Regeneration
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Inflammation and Regeneration 30 (1), 34-39, 2010
一般社団法人 日本炎症・再生医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205258640768
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- NII論文ID
- 10026094188
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- NII書誌ID
- AA11508953
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- ISSN
- 18808190
- 18809693
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- NDL書誌ID
- 10571526
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可