Regulatory T cells in the control of T cell homeostasis

DOI Web Site 参考文献50件
  • Kawahata Kimito
    Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
  • Kanzaki Takeyuki
    Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
  • Imamura Mitsuru
    Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
  • Akahira Lisa
    Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
  • Michishita Kazuya
    Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
  • Dohi Makoto
    Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
  • Yamamoto Kazuhiko
    Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

この論文をさがす

説明

Lymphopenia results in homeostatic peripheral expansion of lymphocytes in order to maintain T-cell homeostasis. T-cell homeostasis requires the regulation of lymphocytes numbers, function, and diversity responsive to foreign antigen and the maintenance of self-tolerance during lymphopenia-induced proliferation. Accumulating data elucidate that regulatory T cells critically contribute to the control of T cell homeostasis. Moreover, recent studies show that regulatory T cell homeostasis requires the co-existence with conventional T cells which can produce IL-2. Thus, T-cell homeostasis is maintained by the close interactions between regulatory T cells and conventional T cells. Understanding the mechanisms of homeostatic proliferation will lead to new therapeutic interventions for autoimmune diseases.

収録刊行物

参考文献 (50)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ