生体内で作る人工臓器ジェリーフィッシュ弁・弁葉

書誌事項

タイトル別名
  • Artificial Organ Made in vivo —Valve Leaflet of the Jellyfish Valve—
  • 生体内で作る人工臟器ジェリーフィッシュ弁・弁葉
  • セイタイナイ デ ツクル ジンコウ ゾウキ ジェリーフィッシュベン ベンヨウ

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抄録

Artificial materials used for artificial organs have sufficient strength and durability. However, their biocompatibility has not been improved yet to the level of tissue-derived biomaterials. On the other hand, there were some problems in artificial organs made of tissue-derived biomaterials; difficulty of forming the desired shapes, insufficiency of strength and durability, and infection control. It is necessary to build arbitrarily-shaped artificial organs that have sufficient strength and durability with tissue-derived biomaterials. In this study, we developed an in-vivo method to make a circle valve leaflet of a jellyfish valve using an insert molding technique. The jellyfish valve is an artificial valve developed at the University of Tokyo, and consists of the valve leaflet and a valve seat. The three types of molds for valve leaflets with different thickness (0.5 mm, 1.0 mm, and 1.2 mm) were made with an acrylic resin. A velour cloth was put inside each mold to ensure strength and durability. Two sets of molds were built; one with only suspended cell and another with both suspended cell and tissue fragments. Three types of molds were implanted under the skin of a goat. The performance and durability of jellyfish valves with tissue-engineered valve leaflets were assessed using a mock circulation circuit after the molds were extracted from the goats and the valve leaflets were fixed with formalin. Moreover, hematoxylin-and-eosin stained sections were observed. The results demonstrated that the valve leaflets covered with connective tissues have sufficient performance and durability of more than one month. In conclusion, we made a tissue-engineered circle valve leaflet with enough strength and durability to be used as heart valves in vivo using the insert molding technique.

収録刊行物

  • 生体医工学

    生体医工学 45 (4), 267-273, 2007

    公益社団法人 日本生体医工学会

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