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- 岸 亜由美
- 北里大学大学院医療系研究科
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- 磯山 隆
- 東京大学大学院医学系研究科医用生体工学
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- 斎藤 逸郎
- 東京大学先端科学技術研究センター
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- 河野 明正
- 東京大学大学院医学系研究科医用生体工学
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- 小野 俊哉
- 東京大学大学院医学系研究科医用生体工学
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- 杉野 礼佳
- 東京大学大学院医学系研究科医用生体工学
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- 光宗 倫彦
- 東京大学先端科学技術研究センター
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- 山口 さち子
- 東京大学大学院医学系研究科医用生体工学
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- 時 偉
- 東京大学大学院医学系研究科医用生体工学
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- 井上 雄介
- 東京大学大学院医学系研究科医用生体工学
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- 中川 英元
- 東京大学先端科学技術研究センター
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- 阿部 裕輔
- 東京大学大学院医学系研究科医用生体工学
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- 井街 宏
- 東北大学TUBERO
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- 野城 真理
- 北里大学大学院医療系研究科
書誌事項
- タイトル別名
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- Artificial Organ Made in vivo —Valve Leaflet of the Jellyfish Valve—
- 生体内で作る人工臟器ジェリーフィッシュ弁・弁葉
- セイタイナイ デ ツクル ジンコウ ゾウキ ジェリーフィッシュベン ベンヨウ
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抄録
Artificial materials used for artificial organs have sufficient strength and durability. However, their biocompatibility has not been improved yet to the level of tissue-derived biomaterials. On the other hand, there were some problems in artificial organs made of tissue-derived biomaterials; difficulty of forming the desired shapes, insufficiency of strength and durability, and infection control. It is necessary to build arbitrarily-shaped artificial organs that have sufficient strength and durability with tissue-derived biomaterials. In this study, we developed an in-vivo method to make a circle valve leaflet of a jellyfish valve using an insert molding technique. The jellyfish valve is an artificial valve developed at the University of Tokyo, and consists of the valve leaflet and a valve seat. The three types of molds for valve leaflets with different thickness (0.5 mm, 1.0 mm, and 1.2 mm) were made with an acrylic resin. A velour cloth was put inside each mold to ensure strength and durability. Two sets of molds were built; one with only suspended cell and another with both suspended cell and tissue fragments. Three types of molds were implanted under the skin of a goat. The performance and durability of jellyfish valves with tissue-engineered valve leaflets were assessed using a mock circulation circuit after the molds were extracted from the goats and the valve leaflets were fixed with formalin. Moreover, hematoxylin-and-eosin stained sections were observed. The results demonstrated that the valve leaflets covered with connective tissues have sufficient performance and durability of more than one month. In conclusion, we made a tissue-engineered circle valve leaflet with enough strength and durability to be used as heart valves in vivo using the insert molding technique.
収録刊行物
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- 生体医工学
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生体医工学 45 (4), 267-273, 2007
公益社団法人 日本生体医工学会
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詳細情報 詳細情報について
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- CRID
- 1390001205268414080
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- NII論文ID
- 110006614029
- 130004494014
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- NII書誌ID
- AA11633569
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- ISSN
- 18814379
- 1347443X
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- NDL書誌ID
- 9389178
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可