Tissue Engineering using Nanofiber

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  • ナノファイバーを利用した再生医療
  • ナノファイバー オ リヨウ シタ サイセイ イリョウ

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Abstract

Electrospinning (ESP) is a powerful method to produce polymer fibers with nanometer-scale diameters. This article describes the application of nanofiber using polylactic acid for tissue engineering. The diameter and surface structure of nanofiber were easily controlled by the conditions of the ESP.<BR>The influences of fiber diameter on cell adhesion and proliferation were examined by culutivating NIH 3 T 3 (fibroblast cell) on nanofibrous meshes. As a result, it was proved that the control of cell adhesion and proliferation was accomplished with changing a fiber diamter.<BR>We succeeded in the production of a new biodegradable and elastic material which was a combined nanofiber with cross-linked elastin. The obtained tubular material showed excellent mechanical property equal to blood vessel and peripheral nerve tissue. Finally, the regeneration of peripheral nerve axon was observed by transplantation using rat model with sciatic trauma.

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