クエン酸第一鉄塩と硫酸第一鉄のラット貧血回復効果の比較

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書誌事項

タイトル別名
  • Therapeutic Comparison of Tetrasodium Monoferrous Dicitrate with Ferrous Sulfate on the Iron Defficient Anemia in Rats
  • クエンサン ダイ1テツエン ト リュウサン ダイ1テツ ノ ラット ヒンケツ カイフク コウカ ノ ヒカク

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説明

Tetrasodium monoferrous dicitrate (abbreviated to FC) was easily dissolved and remained stable in water at wide pH range, as a low molecular chelate. Although 80% of ferrous iron was oxidized to ferric form in neutral medium, it remained absorbable by the intestine.<BR>The rates of intestinal absorption and utilization of this compound were compared with those of ferrous sulfate by per oral administration to anemic rats. The compounds (0.3mg Fe/rat in each time) were administered by ten times doses during ll days and the recovery of Hb value was assayed at every three days interval and accumulation of nonhemin iron in liver and spleen was determined after 48 hours of the last administration. 59Fe labeled compounds were administered with the first dose to determine the rate of the intestinal absorption. The rate of intestinal absorption of 59Fe was anemia dependent and significantly increased from 5% in normal rats to 70% in severe anemic rats, and it was also clearly shown that the incorporation of iron into hemoglobin had preference to the accumulation of nonhemin iron in liver in both compounds.<BR>The utilization of FC for anemic rats was recognized closely to correspond with that of ferrous sulfate except that the recovery of Hb value tended to be more rapid in the midway and the accumulation of nonhemin iron in liver was smaller than the animals administered ferrous sulfate.

収録刊行物

  • 栄養と食糧

    栄養と食糧 26 (1), 53-57, 1973

    公益社団法人 日本栄養・食糧学会

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