Asymmetric Syntheses Utilizing Mild Activations by Organocatalysts
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- Asano Keisuke
- Graduate School of Engineering, Kyoto University
Bibliographic Information
- Other Title
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- 穏和な有機触媒がもたらす精密不斉合成
- オンワ ナ ユウキ ショクバイ ガ モタラス セイミツ フセイ ゴウセイ
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Abstract
<p>Organocatalysts utilize various molecular interactions for catalysis. However, molecular interactions for organocatalysis are in general not as strong as those for metal-catalysis. Thus, because of this character, multiple activations are often necessary to catalyze a reaction, however, in other words, it enables the use of multipoint interactions in the transition state of a catalytic reaction, thereby leading to high stereoselectivity, even if it is a very rapid reaction. On the basis of this concept, we developed asymmetric reactions affording various heterocycles via organocatalytic hetero-Michael additions and the applied synthetic transformations. In order to accomplish high enantioselectivity, we designed reactions utilizing different activation manners by organocatalysts depending on the substrate type; it is a key to utilize simultaneous multipoint interactions between a catalyst and a substrate.</p>
Journal
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- Journal of Synthetic Organic Chemistry, Japan
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Journal of Synthetic Organic Chemistry, Japan 74 (12), 1194-1205, 2016
The Society of Synthetic Organic Chemistry, Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001205338892544
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- NII Article ID
- 130005251191
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- NII Book ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL BIB ID
- 027791209
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed