日向熱病原体に関する研究
書誌事項
- タイトル別名
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- STUDIES ON THE PATHOGENIC ORGANISM OF THE HYUGANETSU DISEASE
- (I) CULTIVATION OF THE NAKAZAKI STRAIN IN YOLK SACS AND CULTIVATION IN TISSUES OF WHOLE EMBRYONIC MICE
- 第1報 中崎株の孵化鷄卵々黄嚢内培養並にマウス全胎児組織えの培養
説明
The pathogenic organism of the Hyuganetsu disease, regarded as infectious mononucleosis, was isolated in Japan. However, many doubts remain in that the pathogenic organism is the causative agent of real infectious mononucleosis. On the other hand, the Tsutsugamushi disease seems to be included in the Hyuganetsu disease. The present authors have made investigations concerning the cultivation of the Nakazaki strain, which was isolated as the causative agent of the Hyuganetsu disease, in yolk sacs and the cultivation in tissues of whole embryonic mice. These results are obtained as follows:<br>1) The Nakazaki strain was successfully cultivated in yolk sacs only up to the 4th passage. 2) Cultivation in tissues of whole embryonic mice was successfully conducted. The infectivity of tissues increased to approximately 100-1000 times after 15 days of cultivation and the cultivation in vitro was successfully continued during at least 30 days by two passages.<br>3) At this time, the addition of hyaluronidase in the materials for inoculation promoted the establishment of infection and the cultivation was accelerated by this addition. 4) The pathogenic organisms propagated in the cytoplasma of cultivated tissues were either coccoid or oval in shape, approximately 0.3-0.4μ in diameter, under the photomicroscope. There was no remarkable variation compared with that of prepared from the living body.
収録刊行物
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- ＶＩＲＵＳ
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ＶＩＲＵＳ 6 (6), 471-477, 1956
日本ウイルス学会
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詳細情報 詳細情報について
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- CRID
- 1390001205343614976
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- NII論文ID
- 130003854318
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- ISSN
- 18843425
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
