Clinical pharmacology of 2, 3-dichloro-4-methoxyphenyl 2-furyl ketone (E)-0- [2-(diethylamino) ethyl] oxime (ANP 4364) in healthy volunteers
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- NAKASHIMA Mitsuyoshi
- Department of Pharmacology, Hamamatsu University School of Medicine
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- SUZUKI Kunifumi
- Department of Pharmacology, Hamamatsu University School of Medicine
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- HASHIMOTO Hisakuni
- Department of Pharmacology, Hamamatsu University School of Medicine
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- OGURO Katsunori
- Department of Pharmacology, Hamamatsu University School of Medicine
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- NISHIJIMA Kenji
- Cardiovascular Division, Hamamatsu Medical Center
Bibliographic Information
- Other Title
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- 2, 3-Dichloro-4-methoxyphenyl 2-furyl ketone (E)-0 [2-(diethylamino) ethyl] oxime (ANP 4364) の健康人における臨床薬理学的検討
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Description
A newly synthesized ketone oxime derivertive, 2, 3-dichloro-4-methoxyphenyl 2-furyl ketone (E)-0- [2-(diethylamino) ethyl] oxime (ANP 4364), was administered orally to 6 healthy volunteers to investigate its safety, pharmacodynamics, and pharmacokinetics.<BR>Six volunteers received single oral doses of 50, 100, 200 mg, and 3 consecutive doses of 100 mg, of ANP 4364.<BR>ANP 4364 caused slight hypotension, with a transient tachycardia, and a tendency towards increasing stroke volume revealed by impedance cardiography.<BR>No findings attributable to the drug were observed in the ECG or body temperature records.<BR>Pharmacokinetic analysis revealed that unchanged ANP 4364 was rapidly absorbed with a mean half-life of about 10 hours. After administration of 100 mg, 0.16% of the dose of ANP 4364 was excreted in urine within 24 hours. Subjective symptoms possibly produced by the drug were headache, a heavy feeling of the head, a feeling of warmth in the face, and numbness of the tongue ; there was one subject, however, who complained of nausea.<BR>Examination of the blood and urine showed no abnormal findings attributable to administration of the drug.<BR>In conclusion, it was found that ANP 4364 seems to have vasodilating action and is well-tolerated in man.
Journal
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- Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
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Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 10 (4), 495-507, 1979
The Japanese Society of Clinical Pharmacology and Therapeutics
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Details 詳細情報について
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- CRID
- 1390001205367354752
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- NII Article ID
- 130002048217
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- ISSN
- 18828272
- 03881601
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed