2, 3-Dichloro-4-methoxyphenyl 2-furyl ketone (E)-0 [2-(diethylamino) ethyl] oxime (ANP 4364) の健康人における臨床薬理学的検討
書誌事項
- タイトル別名
-
- Clinical pharmacology of 2, 3-dichloro-4-methoxyphenyl 2-furyl ketone (E)-0- [2-(diethylamino) ethyl] oxime (ANP 4364) in healthy volunteers
この論文をさがす
説明
A newly synthesized ketone oxime derivertive, 2, 3-dichloro-4-methoxyphenyl 2-furyl ketone (E)-0- [2-(diethylamino) ethyl] oxime (ANP 4364), was administered orally to 6 healthy volunteers to investigate its safety, pharmacodynamics, and pharmacokinetics.<BR>Six volunteers received single oral doses of 50, 100, 200 mg, and 3 consecutive doses of 100 mg, of ANP 4364.<BR>ANP 4364 caused slight hypotension, with a transient tachycardia, and a tendency towards increasing stroke volume revealed by impedance cardiography.<BR>No findings attributable to the drug were observed in the ECG or body temperature records.<BR>Pharmacokinetic analysis revealed that unchanged ANP 4364 was rapidly absorbed with a mean half-life of about 10 hours. After administration of 100 mg, 0.16% of the dose of ANP 4364 was excreted in urine within 24 hours. Subjective symptoms possibly produced by the drug were headache, a heavy feeling of the head, a feeling of warmth in the face, and numbness of the tongue ; there was one subject, however, who complained of nausea.<BR>Examination of the blood and urine showed no abnormal findings attributable to administration of the drug.<BR>In conclusion, it was found that ANP 4364 seems to have vasodilating action and is well-tolerated in man.
収録刊行物
-
- 臨床薬理
-
臨床薬理 10 (4), 495-507, 1979
一般社団法人 日本臨床薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205367354752
-
- NII論文ID
- 130002048217
-
- ISSN
- 18828272
- 03881601
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可